Monday, September 14, 2020

"Who Wants to Live Forever?"

"Who Wants to Live Forever?"
by Mark Manson

"Each week, I send you three potentially life-changing ideas to help you be a slightly less awful human being. This week, we’re talking about topics that are a matter of life and death. No seriously, we’re talking about life and death this week: 1) the scientific progress in "treating" aging, 2) what a vastly longer lifespan would mean for culture and society, and 3) why do things die in the first place? Let’s get into it.

1. Can aging be reversed? - One of the more quietly controversial and interesting areas of scientific progress today is around the idea that biological aging can be treated as a disease and potentially be reversed. For years, researchers have been pioneering methods to limit cellular deterioration, stave off chronic diseases, and help older individuals stay healthy and independent as life expectancies rise.

Last week, a new study found that a cocktail of drugs not only slowed biological aging (measured by markers on the individual’s genome), it reversed it by approximately 2.5 years. To my knowledge, this is the first time an aging reversal has been shown in human subjects. This is a stunning result that even the researchers did not expect. (Note: it was a small study and had no control group, so don’t wet your panties just yet. As always, more studies need to be done.)

As with most bleeding-edge technologies, the idea that we can defeat aging, like most controversial ideas, has inspired reactions from experts that range from utopian to apocalyptic.

I was first exposed to the idea that aging could potentially be conquered by science in Ray Kurzweil’s book "The Singularity is Near." In it, Kurzweil's’ views are beyond utopian. They're like the religious rapture. In the book, Kurzweil makes the argument that not only will we cure death, but it will likely happen in most of our lifetimes.

Kurzweil points out that over human history, not only has life expectancy been increasing, but the rate at which it increases has been increasing as well. So, maybe centuries ago, life expectancy increased at a rate of 0.01 years per year. Then, it increased to 0.1 per year. Then 0.2 per year. Then 0.3 per year. He argues that eventually, life expectancy will hit a tipping point where it increases by at least one year per year, meaning that for every year that goes by, humans are expected to live at least one year longer. Ergo, we all become immortal. The end.

Maybe Kurzweil hasn’t spent much time investing in financial markets, otherwise, he’d be aware of the ubiquitous warning that accompanies every exciting chart: "Warning: Past performance is no guarantee of future results."

Indeed, there seems to be a "low-hanging fruit" effect on human longevity. It turns out that giving most of the world running water, sewage treatment, and, you know, food, vastly increases lifespan. So that "exponential curve" of increasing life expectancy that forever increases into the future is more likely an "S-curve" where life expectancy jumps massively as countries industrialize and modernize and then begin to level off at around 75-80 years old.

But regardless of the murky science and controversial implications, the lure of immortality is too strong for many to ignore. Companies have emerged that offer to cryogenically freeze your body when you die, promising to keep you frozen until the technology to "cure death" emerges in the future.

No, I’m not making this stuff up. Apparently, some notable people such as Larry King and Peter Thiel have signed up for it. But don’t get too excited. Freezing your body indefinitely after death starts at around $200,000 USD. Better start saving today!

2. Who wants to live forever? - In my book, "Everything is F***ed: A Book About Hope", I argued that one of the dangers of consumer culture is that we often equate "giving people what they want" with progress. Given that we so often want things that are terrible for ourselves (not to mention others), I point out that this is a pretty flimsy standard for measuring the social good.  

To me, curing aging (and maybe even death) is the ultimate question of, "Okay, we definitely want it… but should we?"

It’s hard to imagine the social and psychological repercussions of a population where the average life expectancy is, say, 250 years old. Would we overpopulate the planet? When would the retirement age be? Would our healthcare systems collapse? Would bridge and bingo become Olympic sports?

I joke, but I do think there are some serious philosophical questions here. Our ability to value things is driven by scarcity. We often care about things in our lives because we have an abiding sense that we will never experience them again. If we live forever, all experience becomes abundant, therefore much of it loses its meaning. Everything becomes more superficial—there’s no sense of legacy, no sense of, "I lived for that."

Or what about family? Will it become standard for everyone to have half a dozen marriages and a dozen kids? Will people have brothers and sisters 70 years younger or older than themselves? Will we appreciate our parents more or less knowing that we’re stuck with them for another two centuries and will end up sharing them with dozens of other people?

The perceived costs of things like traffic accidents, disease, and war would become much larger. Far fewer people would want to risk getting shot or dying in a car accident if they know they’re giving up hundreds of years of life. People would oddly become much more risk-averse. Pandemics would be waaaay scarier. The power of compound interest would become far more valuable, creating much more of a culture around saving and learning rather than spending and doing. Expertise would reach a point where people spend 30 or 40 years getting educated before starting their careers. Forty really would be the new twenty!

3. The evolutionary value of death - You might read all this and throw your hands up in the air and shout, "What are they doing? This isn’t natural!" But you’d be wrong.

Although they are rare, there are "immortal" species on the planet (in this case, "immortal" means that they do not biologically age.) The jellyfish Turritopsis dohrnii doesn’t die. Neither does the bristlecone pine tree. Many species of lobster technically don’t age and could theoretically live forever, the problem is that they outgrow their shells which then decay and fall apart, leaving them vulnerable to predators (talk about tragic).

Lifespans vary widely across the natural world. Some sharks and tortoises live for half a millennia. There are species of apes that only live to be about 15 years old. There are several species of flies that live for 24 hours or less.

It turns out that death is not inevitable. In fact, death exists for a specific evolutionary purpose. Ideally, by mixing and matching genetics, a species becomes more robustly adapted to its environment. The quicker individual creatures die, the faster they must procreate new generations, and the faster the rate of genetic mutation and adaptation within the species.

Therefore, each species has a "sweet spot" for lifespan based on the necessary evolutionary adaptation to its environment. If a species needs to adapt quickly and often, it dies quickly and often. If it needs to adapt slowly (or never), then it dies slowly (or never).

That "sweet spot" for humans seems to be every 2-3 generations, or every 80-100 years. The telomeres on our chromosomes appear to "run out" soon after that, effectively putting a limit on how long we can live naturally. This sweet spot probably exists because it’s short enough to stay ahead of the quickly mutating infectious diseases that threaten us, but long enough to have some grandparents around to help raise kids (for more on this idea, see Matt Ridley’s excellent book, "The Red Queen").  

A lot has been said about the scientific potential to alter our own species - genetic engineering, nanotechnology, artificial intelligence, etc. But perhaps nothing would be so fundamental as altering our ability to age and die. Our psychology, our biology, and our societies seem to be largely based on it. Changing it could change everything. The question is, will we be around to see it? Until next week,"

1 comment:

  1. Watch (or read) "Altered Carbon" by Richard Morgan. It describes a society where death can be indefinitely postponed in most cases by backing up one's consciousness on what is equivalently a small hard drive, to be "resleeved" indefinitely in other bodies.

    ReplyDelete